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Year : 2015  |  Volume : 1  |  Issue : 1  |  Page : 54-56

Non-Hodgkin lymphoma unclassifiable between diffuse large B-cell lymphoma and Burkitt lymphoma

1 Department of Pathology, All Institute of Medical Sciences, New Delhi, India
2 Department of Medical Oncology, All Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Saumyaranjan Mallick
Department of Pathology, All India Institute of Medical Sciences, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

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Large B-cell lymphomas are the most common non-Hodgkin lymphoma representing a heterogeneous group of diseases which often pose diagnostic problems in the clinical practice. B-cell lymphoma, unclassifiable (B-UCL), with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, is a poorly defined rare entity. We describe a 59-year-old male patient presented with complaints of bloody nasal discharge for last few months. On examination, a nasal mass was seen. Biopsy revealed a non-Hodgkin lymphoma. The cells are immune positive for CD20, BCL-2, BCL-6, and MUM-1. Ki-67 labeling index was 90% while negative for CD1 and CD5. A diagnosis of B-UCL was made. This case is presented due to its diagnostic difficulty among large B-cell lymphomas and emphasizes the need to integrate morphological and immunohistochemical findings.

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