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  Indian J Med Microbiol
 

Figure 1: Schematic diagram of the mechanism of action of lasmiditan. Lasmiditan is an agonism of 5HT1F receptor (coupled to the Gi protein and mediates inhibitory neurotransmission), which inhibits adenylate cyclase decreasing the cyclic adenosine monophosphate and consequently the protein kinase A action. This general decrease of phosphorylation causes: (1) reduction of the cyclic adenosine monophosphate response element-binding activity and possibly resulting in low levels of c-Fos; (2) reduction of histamine release, which does not change the vascular permeability decreasing the dural plasma protein extravasation (3) reduction of calcitonin gene-related peptide release

Figure 1: Schematic diagram of the mechanism of action of lasmiditan. Lasmiditan is an agonism of 5HT1F receptor (coupled to the Gi protein and mediates inhibitory neurotransmission), which inhibits adenylate cyclase decreasing the cyclic adenosine monophosphate and consequently the protein kinase A action. This general decrease of phosphorylation causes: (1) reduction of the cyclic adenosine monophosphate response element-binding activity and possibly resulting in low levels of c-Fos; (2) reduction of histamine release, which does not change the vascular permeability decreasing the dural plasma protein extravasation (3) reduction of calcitonin gene-related peptide release