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ORIGINAL ARTICLE
Year : 2018  |  Volume : 4  |  Issue : 1  |  Page : 52-57

Antihyperlipidemic activity of Hridayarnava Rasa (an Ayurvedic herbo-metalo-mineral formulation) in Charles Foster albino rats


1 Central Ayurveda Research Institute for Drug Development, Kolkata, West Bengal, India
2 Pharmacology Laboratory, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India
3 Department of Rasashastra and Bhaishajya Kalpana, AIIA, New Delhi, India

Correspondence Address:
Swapnil Y Chaudhari
Central Ayurveda Research Institute for Drug Development, Kolkata, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcrsm.jcrsm_68_17

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Background: Hyperlipidemia is modifiable risk factor for cardiovascular diseases, and its prevalence is alarmingly increased in India. Although many treatment modalities are effectively used in the conventional system, they have certain limitations and adverse effects. Ayurvedic metallic and herbo-mineral formulations are safely practiced in Indian subcontinent without any noticeable side effects. Hridayarnava Rasa is one such Ayurvedic herbo-metalo-mineral formulation containing Tamra Bhasma (incinerated copper) as an integral component that is being successfully prescribed in the management of lipid disorders. Materials and Methods: Tamra Bhasma is prepared with different Amritikarana methods which are said to eliminate all the blemishes from the end product and increases its therapeutic efficacy. The antihyperlipidemic activity of Hridayarnava Rasa prepared from Tamra Bhasma processed in Panchamrita (HRTBP) was carried out in Charles Foster albino rats having hyperlipidemia induced by high-fat diet. The parameters including body weight, organ weight, serum lipid profile, and histopathology of liver, heart, kidney, and aorta were studied. Results and Coclusion: Results revealed that HRTBP attenuated increased lipid profile and pathological changes in heart, liver, and kidney induced by administration of hyperlipidemic diet. Hridayarnava Rasa has shown mild antihyperlipidemic activity in experimental animals. Background: Hyperlipidemia is modifiable risk factor for cardiovascular diseases, and its prevalence is alarmingly increased in India. Although many treatment modalities are effectively used in the conventional system, they have certain limitations and adverse effects. Ayurvedic metallic and herbo-mineral formulations are safely practiced in Indian subcontinent without any noticeable side effects. Hridayarnava Rasa is one such Ayurvedic herbo-metalo-mineral formulation containing Tamra Bhasma (incinerated copper) as an integral component that is being successfully prescribed in the management of lipid disorders. Materials and Methods: Tamra Bhasma is prepared with different Amritikarana methods which are said to eliminate all the blemishes from the end product and increases its therapeutic efficacy. The antihyperlipidemic activity of Hridayarnava Rasa prepared from Tamra Bhasma processed in Panchamrita (HRTBP) was carried out in Charles Foster albino rats having hyperlipidemia induced by high-fat diet. The parameters including body weight, organ weight, serum lipid profile, and histopathology of liver, heart, kidney, and aorta were studied. Results and Coclusion: Results revealed that HRTBP attenuated increased lipid profile and pathological changes in heart, liver, and kidney induced by administration of hyperlipidemic diet. Hridayarnava Rasa has shown mild antihyperlipidemic activity in experimental animals.


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