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ORIGINAL ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 24-28

The effect of the antioxidant drug "U-74389G" on salpingitis during ischemia-reperfusion injury in rats


1 Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
2 Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Pikermi, Attica, Greece
3 Department of Surgery, Ippokrateio General Hospital, Athens University, Pikermi, Attica, Greece
4 Department of Biologic Chemistry, Athens University, Pikermi, Attica, Greece
5 Experimental Research Centre, ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attica, Greece

Correspondence Address:
Constantinos Tsompos
Department of Obstetrics and Gynecology, Mesologi County Hospital, Nafpaktou Street, Mesologi 30200, Etoloakarnania
Greece
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2455-3069.184125

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Objective: This experimental study examined the effect of the antioxidant drug "U-74389G," on rat model and particularly in an oviductal ischemia-reperfusion (IR) protocol. The probable beneficial effect of that molecule was studied pathologically using mean salpingitis (S) lesions. Materials and Methods: Forty rats of mean weight 231.875 g were used in the study. S lesions were evaluated at 60 min of reperfusion (Groups A and C) and 120 min of reperfusion (Groups B and D), A and B without but C and D with the U-74389G administration. Results: U-74389G administration nonsignificantly altered the S scores without S lesions by 0 (P = 1.0000). Reperfusion time nonsignificantly altered the S scores without S lesions by 0 (P = 1.0000). However, U-74389G administration and reperfusion time together nonsignificantly altered the S scores without S lesions by 0 (P = 1.0000). Conclusions: U-74389G administration whether it interacted or not with reperfusion time nonsignificantly altered without lesions the salpingitis lesions within short-term time context of 2 h. Perhaps, a longer study time than 2 h or a higher drug dose may provide significant effects.


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